A Brief History of Tau with Links You Might Need!

A Brief History of Tau

1976, Weiss found Tau.
1992, the first non-invasive calculation.
1992, a formula involving Tau.
1993, an important improvement with decent data.
1995, a similar strategy applied to AI patients.
1995, I published a formula with one assumption.
1997, Cleveland validated the aforementioned formula with 5 hypotheses.
2005, Langer presented a non-zero asymptote model.
2008, I improved my formulas, without assumption now.
2008, I did a similar method in AI patients.
2008, Chen developed program for my formulas, free download.
2008, my poster in ASE 19th Annual Scientific Sessions.
2009, my poster in CSE forum.
2009, DF guideline (ASE) recommended Cleveland's formula.
2009, I gave my opinion about the guideline method.
2009, "Response to Bai" from guideline writing group. It motivated me to create this Blog.
2010, Dr Wang and me pushed Tau to all cardiac functions.
2011-11-29, I gave a talk in National Capital Echo Round (Ottawa)
2016-03-29, I gave a talk at the Heart Institute, the North Hospital (Shenyang, China)
2016-04-01, I gave a talk at the Cardiac Function Dept., the 1st Clinical College, Chinese University of Medicine. (Shenyang, China)
2016, Symmetry inspired by Tau
2017, Calculation of LAP got Chinese Natural Science Founding.
2017, Mindray made the first Tau measurable ultrasound machine.

Saturday, October 16, 2010

CAAM, a clinical call for help from the echo engineers.

Accurate measurement of time intervals is critically important for successful Tau calculation. Garbage in, garbage out. But don't hesitate to move forward. We just need something like computer aided accurate measurement, CAAM. I figured out this word. :)

We are interogating the regurgitation by continuous wave Doppler. There are two different pieces of quartz crystals to emit the ultrasound and receive the echo separately. Theoretically, since there is no “waiting time” as needed in pulse wave Doppler, we can follow up every movement of the leaking RBCs, and the modern computer makes it possible to do the quick data processing. By that means, we can measure the two time intervals as accurate as we need.

On the other hand, the echo engineers can give us a pure curve instead of a “spectrum”. This pure curve is supposed to be a reasonably smoothed spectrum. Compared with regular spectrum, the curve is superior in consistancy, accuracy and automatic measurement.

So, the need to measure time intervals accurate is not doom of Tau calculation, it is boom of a fresh perspective in ultrasound. Just like in CT reading, there is a similar clinical call for CAAM.

This is the equation group used to calculate Tau in MR pt:

Tau = (t1-t2) / ln((16 + LAP -C) / (4 + LAP -C))
Tau = (t1-t3) / ln((36 + LAP -C) / (4 + LAP-C))

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