Is Tau dispensable?

Left ventricular diastolic time constant, Tau is the most established index to describe diastolic function. A Harvard method of Tau was invented by Dr JD Thomas has been dominant non-invasive Tau measurement for more than two decades. Now, Tau is dead clinically. Only when the logically flawed celebrity method is objectively reassessed and discarded, can Tau be given a chance. A new method is dawning and promising…

A Brief History of Tau with Links You Might Need!

A Brief History of Tau

1976, Tau was born in John Hopkins.
1992, the first non-invasive try, Harvard.
1992, the first formula, with four assumptions, Harvard.
1993, another non-invasive try with decent data, Mayo Clinic.
1995, a similar strategy applied to AI patients, Japan.
1995, I published a MR based formula with one assumption.
1997, the Harvard formula was validated in Cleveland.
2005, Langer presented a non-zero asymptote model.
2008, I improved my MR based formulas, without assumption.
2008, I did a similar deduction for AI based Tau.
2008, Chen developed program for my formulas, free download.
2008, my poster in ASE 19th Annual Scientific Sessions.
2009, my poster in CSE forum.
2009, DF guideline (ASE) recommended Harvard formula.
2009, I gave my opinion about the guideline recommendation.
2009, "Response to Bai" from guideline writing group. It motivated me to create this Blog.
2010, Dr Wang and me presented general Tau.
2011-11-29, I gave a talk in National Capital Echo Round (Ottawa)
2016-03-29, I gave a talk at the Heart Institute, the North Hospital (Shenyang, China)
2016-04-01, I gave a talk at the Cardiac Function Dept., the 1st Clinical College, Chinese University of Medicine. (Shenyang, China)
2016, Symmetry inspired by the approach of Tau.
2017, Calculation of LAP (based on my formulas) got a Chinese Natural Science Founding.

Sunday, June 28, 2020

The Harvard Method of Tau Papers Should be Retracted

The Harvard method was invented in 1992 by Dr James Thomas from Harvard and got a brief experimental verification.


Thomas JD, Flachskampf FA, Chen C, Guererro JL, Picard MH, Levine RA, Weyman AE. Isovolumic relaxation time varies predictably with its time constant and aortic and left atrial pressure: implications for the noninvasive of ventricular relaxation. Am Heart J. 1992;124:1305–1313. [PubMed] [Google Scholar]


Five years later, the method was clinically verified at Cleveland and the result was published in Circulation. 


Scalia GM, Greenberg NL, McCarthy PM, Thomas JD,Vandervoort PM. Noninvasive assessment of the ventricular relaxation time constant in humans by Doppler echocardiography. Circulation. 1997;95:151–155. [PubMed] [Google Scholar]


Simple and clear, the formula has logic flaws:


To prove a flawed formula, the authors had to fabricate evidence. Nobody can get "meaningful" data by unintentional mistakes. 

For more than two decades, quite a few projects have been based on the Harvard method of Tau. This is embarrassing. 

Please get the above two "fake testimony" papers retracted.

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