Raymond Stainback, MD, FASE
Texas Heart Institute, Baylor St. Luke’s Medical Center
Dear Mr. president,
On behalf of a bunch of Tau enthusiasts, please investigate a research misconduct with many connections to ASE.
Tau, left ventricular diastolic time constant is well accepted as the most established index to describe diastolic function. Unfortunately, nobody is measuring it in daily clinic as a direct consequence of this research misconduct.
A distinguished ASE member, Dr James Thomas invented a Tau formula that is logically flawed.
Both its experimental and clinical “verification” has to be motivated reasoning. Nobody can get good data with unintentional mistakes. Anyone can tell it is not working by simply checking it on a random patient. The result will go to nowhere. Nevertheless, this incorrect theory has been recommended in both ASE’s textbooks and diastolic function guidelines till today.
Fair to say motivated reasoning is not strange in researchers. If an influential researcher used it to justify a wrong method or a tool, it is like put the lighthouse on a wrong place. Traumatic events could follow in consequence of the reckless behaviour.
Not only the incorrect theory is misleading, but also it has negative effect on genuine Tau research and development. All the papers mentioned here had been rejected several times by mainstream journals, yet measurement of Tau thrived on the other side of the planet. Mindray launched the first Tau-measurable Echo machine 5 years ago.
Tau is the only one index directly related to how powerful the cardiac muscle is. Once it is excluded, all the approaches from the ASE diastolic function guidelines have to be indirect descriptions. Comparison with Tau, the routine assessment of diastolic function could be inaccurate up to around 30% of the studies. We can elaborate it on request.
Tens of thousands of diastolic dysfunction diagnoses are made everyday in the world.
Imagine up to 30% could be inaccurate!
Imagine some of the patients got treatment based on those diagnoses!
Imagine sometimes the treatment is invasive, like IASD…
Please investigate and give Tau a chance, which is consistent with the mission of “to advance cardiovascular ultrasound and improve lives through excellence in education, research, innovation, advocacy, and service to the profession and the public.”
Please don’t hesitate to let me know if further explanation is needed.
Xufang Bai, MD, PhD